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Displaying 51-100 of 270 results.
TitelPromovendusPromotor 1Promotor 2Copromotor 1Copromotor 2UniversiteitPromotiejaarTrefwoorden
Neurovascular pharmacology of migraine: epigenetics and sex hormonesLabruijere S., PhDDanser A.H.J., prof. dr.Maassen van den Brink A., dr.Erasmus Universiteit Rotterdam (EUR)2014Pharmacology; Migraine; Epigenetics; Neurovascular pharmacology;
Challenges in using cardiovascular medications in Sub-Saharan AfricaBerhe D.F., PhDHaaijer-Ruskamp F.M., prof. dr.Taxis K., prof. dr.Mol P.G.M., dr.Rijksuniversiteit Groningen (RUG)2017Pharmacology; Medication use; Cardiovascular disease;
Cardiovascular molecular imagingHaas H.J. de, PhDDierckx R.A.J.O., prof. dr.Slart R.H.J.A., prof. dr.Boersma H.H., dr.Rijksuniversiteit Groningen (RUG)2018Pharmacology; Cardiovascular molecular imaging
The alternative renin-angiotensin system: exploration of its therapeutic potentialSevá Pessôa B., PhDDanser A.H.J., prof. dr.Roks A.J.M., dr.Erasmus Universiteit Rotterdam (EUR)2015Pharmacology; Cardiovascular disease; Renin-angiotensin system;
Aortic pathology and the role of the renin-angiotensin systemMolzer E., PhDDanser A.H.J., prof. dr.Erasmus Universiteit Rotterdam (EUR)2011Pharmacology; Cardiovascular disease; Renin-angiotensin system;
Novel directions in therapy against age-related vascular diseaseWu H., PhDDanser A.H.J., prof. dr.Roks A.J.M., dr.Erasmus Universiteit Rotterdam (EUR)2014Pharmacology; Cardiovascular disease;
Advanced vascular imaging : technical and clinical applications in type 2 diabetesBoer S.A. de, PhDKamphuisen T.P.W., prof. dr.Slart R.H.J.A., prof. dr.Rijksuniversiteit Groningen (RUG)2017Pharmacology; advanced vascular imaging; Diabetes mellitus;
The therapeutic potential of Indoleamine 2.3-dioxygenase in kidney transplantationVavrinacova-Yaghi D., PhDHenning R.H., prof. dr.Sandovici M., dr.Seelen M.A.J., dr.Rijksuniversiteit Groningen (RUG)2014Pharmacology; kidney transplantation Indoleamine 2.3-dioxygenase
Pharmacokinetics, pharmacodynamics and safety of different propofol formulationsKnibbe C.A.J., prof. dr.Danhof M., prof. dr.Aarts L.P.H.J., prof. dr.Kuks P.F.M., dr.Universiteit Leiden (UL)2002Pharmacokinetics; Pharmacodynamics; Propofol;
Don't be afraid! Population PK-PD modeling as the basis for individualized dosing in children and critically illPeeters M.Y.M., dr.Danhof M., prof. dr.Tibboel D., prof. dr.Knibbe C.A.J., prof. dr.Universiteit Leiden (UL)2007Pharmacokinetics; Pharmacodynamics; Children; Sedation; Critically ill; Intensive care; NONMEM; Propofol; Midazolam;
Challenges and opportunities in pharmacogenomics: studies in cardiovascular disease and asthmaLeusink M., PhDBoer A. de, prof. dr.Bakker P.I.W. de, prof. dr.Maitland-van der Zee A.H., prof. dr.Onland-Moret N.C., dr.Universiteit Utrecht (UU)2015Pharmacogenomics; Cardiovascular disease; Asthma; Genomics; Genetics; Pharmacology; Statins; Inhaled corticosteroids; Cholesterol;
Use of real-world evidence in pharmaeconomic analysisHuang Y.Haaijer-Ruskamp F.M., prof. dr.Postma M.J., prof. dr.Rijksuniversiteit Groningen (RUG)2019Pharmacogenomics;
Translating pharmacogenetics to primary care Swen J.J., PhDGuchelaar H.J., prof. dr.Assendelft W.J.J., prof. dr.Wessels J.A.M., dr.Universiteit Leiden (UL)2011Pharmacogenetics; Primary care;
Treatment optimization of fluoropyrimidines as single agent and in combination therapyDeenen M.J., PhDSchellens J.H.M., prof. dr.Beijnen J.H., prof. dr.Cats A., dr.Universiteit Utrecht (UU)2011Pharmacogenetics; Fluoropyrimidines; Capecitabine; 5-fluorouracil; Dihydropyrimidine dehydrogenase; Dihydropyrimidine dehydrogenase; DPD-deficiency;
Pharmacogenetics of antihypertensive drug treatmentWieren-de Wijer B.M.A. van, dr.Boer A. de, prof. dr.Stricker B.H.C., prof. dr.Klungel O.H., prof. dr.Maitland-van der Zee A.H., prof. dr.Universiteit Utrecht (UU)2009Pharmacogenetics; Antihypertensive drugs; Study design; Observational studies; UIPS;
Improving acceptance of pharmacogenetic testing in clinical careBank P.C.D., PhD PharmDGuchelaar H.J., prof. dr.Swen J.J., PhDUniversiteit Leiden (UL)2018Pharmacogenetics, pharmacogenomics, primary care, Clinical-decision-support, drug-safety
Continuity of pharmaceutical care for psychiatric patientsAbdullah-Koolmees H., PhDEgberts A.C.G., prof. dr.Heerdink E.R., dr.Gardarsdottir H., dr.Universiteit Utrecht (UU)2015Pharmaceutical care; Medication; Hospitalization; Somatic; Discharge; Discontinuation; Rehospitalization; Rehospitalization prediction;
Exploring strategies to individualize treatment with aminoglycosides and co-trimoxazole for MDR TuberculosisDijkstra J.A., PhDWerf T.S. van der, prof. dr.Kosterink J.G.W., prof. dr.Alffenaar J.W.C., prof. dr.Rijksuniversiteit Groningen (RUG)2017Personalized medicine; Tuberculosis;
Paving ways for personalizing drug therapy during pregnancyDaud N.A.A., PhDWilffert B, prof. dr.Kammen-Bergman J.E.H. van, dr.Rijksuniversiteit Groningen (RUG)2017Personalized medicine; Drug therapy; Pregnancy;
The Clinical Pharmacology of performance enhancement and doping detection in sportsHeuberger J., dr.Cohen A.F., prof. dr.Groeneveld G.J., prof. dr.Rotmans J.I., dr.Universiteit Leiden (UL)2019Performance enhancement and doping detection in sports
Clinical decision support in community pharmacyHeringa M., PhDBouma H.R., PhDSmet P.A.G.M. de, prof. dr.Floor-Schreudering A., PhD PharmDUniversiteit Utrecht (UU)2017Patient safety; Clinical decision support system; Community pharmacy; Drug therapy;
The use of a battery of evoked pain models in early phase drug developmentOkkerse P.Cohen A.F., prof. dr.Groeneveld G.J., prof. dr.Universiteit Leiden (UL)2018Pain Human pain models Analgesics Clinical pharmacology Pharmacodynamics Drug Development
Novel approach to characterize developmental changes in pharmacokinetics across the human lifespan: application to the prediction of clearance in childrenWang C., PhDKnibbe C.A.J., prof. dr.Danhof M., prof. dr.Tibboel D., prof. dr.Universiteit Leiden (UL)2013Paediatrics; Scaling clearance; Population PK; Morphine; Morphine; Paracetamol; Bodyweight-dependent exponent model; Pharmacometrics; Allometric scaling; NONMEM; Pharmacokinetics;
Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in childrenDe Cock R.F.W., PhDKnibbe C.A.J., prof. dr.Danhof M., prof. dr.Allegaert K., prof. dr.Universiteit Leiden (UL)2014Paediatrics; Population PK; Aminoglycosides; Propylene glycol; GFR; Renal function; Antibiotics; Glomerular filtration; Developmental changes; Pharmacokinetics; Newborns;
Size does matter : drug glucuronidation in childrenKrekels E.H.J., PhDKnibbe C.A.J., prof. dr.Tibboel D., prof. dr.Universiteit Leiden (UL)2012Paediatrics; Morphine; Population PK; System-specific covariate modelling; Model validation; Glucuronidation; Ontogeny; Pharmacokinetics; UGT2B7; Zidovudine;
Maturation of cytochrome P450 3A mediated drug metabolism : towards individualized dosing in childrenInce I., PhDTibboel D., prof. dr.Knibbe C.A.J., prof. dr.Wildt S.N. de, prof. dr.Erasmus Universiteit Rotterdam (EUR)2013Paediatrics; Midazolam; CYP3A; Population PK; Maturation; Metabolism;
Child friendly medicines : availability, pharmaceutical design, usability and patient outcomesRiet-Nales D.A. van, PhDSchobben A.F.A.M., prof. dr.Egberts A.C.G., prof. dr.Rademaker C.M.A., dr.Universiteit Utrecht (UU)2014Paediatrics; Drug compounding; Consumer satisfaction; Formulation; Mini tablet; Splitter; Usability; EMA;
Minimally invasive methodology for pharmacological research involving childrenKlein R.H., PhDCohen A.F., prof. dr.Burggraaf J., prof. dr.Sukhai R.N., dr.Universiteit Leiden (UL)2013Paediatrics; Clinical pharmacology; ADHD; Pharmacokinetics; Growth hormone deficiency; Pharmacodynamics; Point of care technology;
How to scale clearance from adults to children for drugs undergoing hepatic metabolism? Insights from advanced PBPK modelling and simulationCalvier E.A.M., PhDKnibbe C.A.J., prof. dr.Tibboel D., prof. dr.Krekels E.H.J., PhDUniversiteit Leiden (UL)2018Paediatrics; Clearance; Allometric scaling; Hepatic metabolism; Physiologically based pharmacokinetics; Pharmacokinetics; Optimal design; Scaling clearance;
Individualization of drug exposure in pediatric hematopoietic stem cell transplantationBartelink I.H., PhDEgberts A.C.G., prof. dr.Danhof M., prof. dr.Boelens J.J., dr.Knibbe C.A.J., prof. dr.Universiteit Utrecht (UU)2012Paediatrics; Busulfan; Hematopoietic stem cell transplantation;
Adherence to antiretroviral combination therapy in children : what a difference half a day makes...Piana C., PhDDanhof M., prof. dr.Della Pasqua O.E., dr.Universiteit Leiden (UL)2013Paediatrics; Antiretroviral combination therapy; Compliance; Antiretroviral drugs; Paediatric populations; Drug combinations; Model-based; Covariate analysis; Predictive pharmacokinetic models; Clinical trial simulations; Adherence; Forgiveness of non-adherence;
Priority medicines for children : exploring age-appropriate medicines and antibiotic use in childrenIvanovska V., PhDLeufkens H.G.M., prof. dr.Mantel-Teeuwisse A.K., dr.Dijk C.E.M.J. van, dr. ir.Universiteit Utrecht (UU)2017Paediatric pharmacotherapy; Paediatric drug development; Priority setting; Age-appropriate formulations; Antibiotic use; Children;
Osteoarthritis : association with diabetes mellitus, and treatment-related outcomesNielen J.T.H., PhDBoonen A.E.R.C.H., prof. dr.Dagnelie P.C., prof. dr.Vries F. de, prof. dr.Bemt B.J.F. van den, dr.Universiteit Maastricht (UM)2018Osteoarthritis; Diabetes mellitus; Hip; Knee; Treatment outcomes;
Challenges in the clinical development of orphan drugsKreeftmeijer-Vegter A.R., PhDBoer A. de, prof. dr.Vries P.J. de, dr.Universiteit Utrecht (UU)2015Orphan drugs; Clinical development; Paediatric formulation; Pharmacokinetics; Efficacy; Safety; Regulatory;
Pharmacological approaches to optimize TB treatmentZuur M.A.Alffenaar J.W.C., prof. dr.Werf T.S. van der, prof. dr.Rijksuniversiteit Groningen (RUG)2018Optimize; Tuberculosis; Treatment;
Exploring optimal pharmacotherapy after bariatic surgery: where two worlds meetYska J.P., PhDRoon E.N. van, prof. dr.Wilffert B, prof. dr.Rijksuniversiteit Groningen (RUG)2017Optimal pharmacotherapy; Bariatric surgery;
Anti sense and sensibility : renal and skin effects of (antisense) oligonucleotidesMeer, van L., Dr.Cohen A.F., prof. dr.Burggraaf J., prof. dr.Moerland M., dr.Universiteit Leiden (UL)2017Oligonucleotide Antisense Type 2 diabetes mellitus Clinical trial Phase2study
Performence of statistical methods to control for unmeasured confounding in pharmacoepidemiology : focus on instrumental variable analysisUddin M.J., MD PhDBoer A. de, prof. dr.Roes K.B.C., prof. dr.Groenwold R.H.H., dr.Klungel O.H., prof. dr.Universiteit Utrecht (UU)2014Observational studies; Pharmacoepidemiology; Confounding; Statistical methods; Instrumental variables; SCCS; PERR;
Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity: Studies in adults, adolescents and childrenSmit C., PhDKnibbe C.A.J., prof. dr.Dongen H.P.A. van, dr.Brüggemann R.J.M., PhDUniversiteit Leiden (UL)2020Obesity; Morbid obesity; Pharmacokinetics; Obese children; Obese adolescents; Gentamicin; Tobramycin; Aminoglycosides; Vancomycin; Renal clearance; Population pharmacokinetics; Antibiotics; Individualized dosing; Adolescents;
Diagnosis and treatment of obese children with insulin resistanceAa M.P. van der, PhDKnibbe C.A.J., prof. dr.Boer A. de, prof. dr.Vorst M.M.J. van der, dr.Universiteit Leiden (UL)2016Obesity; Children; Insulin resistance; Metformin;
Non-invasive monitoring of pharmacokinetics and pharmacodynamics for pharmacological drug profiling in children and adolescentsSchrier L., PhDCohen A.F., prof. dr.Gerven J.M.A. van, prof. dr.Sukhai R.N., dr.Universiteit Leiden (UL)2015Non-invasive monitoring; Pharmacokinetics; Pharmacodynamics; Pharmacological drug profiling; Children; Adolescents;
Challenging the cholinergic system: ageing, cognition & inflammationAlvarez-Jimenez R., PhDGerven J.M.A. van, prof. dr.Cohen A.F., prof. dr.Groeneveld G.J., prof. dr.Universiteit Leiden (UL)2017Neuropsychopharmacology Clinical Pharmacology Trials Cognition Dementia Cholinergis system Drug development
Measuring pharmacodynamics in early clinical drug studies in multiple sclerosisKanhai K.M.SCohen A.F., prof. dr.Groeneveld G.J., prof. dr.Universiteit Leiden (UL)2019Multiple sclerosis Drug development Biomarkers Remyelination
Pain still hurts : pain assessment and pain management in intensive care patientsAhlers S.J.G.M., PhDTibboel D., prof. dr.Knibbe C.A.J., prof. dr.Erasmus Universiteit Rotterdam (EUR)2012Morphine; Remifentanil; Pain; Immune reconstitution; Intensive care; Critically ill; Analgesia; Anesthesiology; Pain assessment; Pain management;
The impact of obesity on the pharmacokinetics of drugs in adolescents and adultsRongen A. van, PhDKnibbe C.A.J., prof. dr.Anker J.N. van den, prof. dr.Dongen H.P.A. van, dr.Ramshorst B. van, dr.Universiteit Leiden (UL)2016Morbid obesity; Pharmacokinetics; Obese adolescents; Midazolam; Acetaminophen; Medication use; Medication use; Metformin;
Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgeryBrill M.J.E., PhDKnibbe C.A.J., prof. dr.Dongen H.P.A. van, dr.Ramshorst B. van, dr.Universiteit Leiden (UL)2016Morbid obesity; Cefazolin; Midazolam; Bariatric surgery; Microdialysis; P53-deficient ovarian cancer; PK-PD modelling;
Peripheral Projections of the Trigeminovascular System as Antimigraine TargetLabastida Ramírez ADanser A.H.J., prof. dr.Maassen van den Brink A., dr.Erasmus Universiteit Rotterdam (EUR)2019Migraine; Vascular reactivity; Pharmacology;
Vascular Effects of Current and Novel Antimigraine DrugsRubio Beltrán AEDanser A.H.J., prof. dr.Maassen van den Brink A., dr.Erasmus Universiteit Rotterdam (EUR)2019Migraine; Vascular reactivity; Drug efficacy; Pharmacology;
Microvasculature, the Trigeminal System and Migraine: A focus on female sex hormonesIbrahimi K., PhDDanser A.H.J., prof. dr.Maassen van den Brink A., dr.Meiracker A.H. van den, dr.Erasmus Universiteit Rotterdam (EUR)2015Migraine; Microvasculature; Trigeminal System; Female Sex Hormones
Intranasal drug delivery in migraineKuy P.H.M. van der, dr.Merkus F.W.H.M., prof. dr.Lohman J.J.H.M., dr.Universiteit Leiden (UL)2003Migraine; Intranasal
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