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Displaying 1-50 of 278 results.
Titel | Promovendus | Promotor 1 | Promotor 2 | Copromotor 1 | Copromotor 2 | Universiteit | Promotiejaar | Trefwoorden |
---|---|---|---|---|---|---|---|---|
Optimizing clinical trial design in chronic kidney disease. | Waijer S.W. | Lambers Heerspink H.J., prof. dr. | Gansevoort R.T., prof. dr. | Rijksuniversiteit Groningen (RUG) | 2022 | Clinical Trial design, Chronic Kidney Diseae | ||
Drug development and new targets for redox disturbances in experimental vascular disease | Henning R.H., prof. dr. | Deelman L.E., dr. | Buikema J.H., dr. | Rijksuniversiteit Groningen (RUG) | 2022 | Drug development, redox disturbance, experimental vascular disease | ||
Clinical pharmacological aspects of mitochondrial function in muscle | Diemen M.P.J. van, PhD | Cohen A.F., prof. dr. | Nelissen R.G.H.H., prof. dr. | Groeneveld G.J., prof. dr. | Universiteit Leiden (UL) | 2021 | Clinical pharmacology; Huntington's disease; Mitochondrial function; Magnetic Resonance Spectroscopy; Sarcopenia; Phosphocreatine recovery rate; Knee; Total knee arthroplasty; Wearables; Peripheral blood mononuclear cells; Protoporphorin IX Triple State Lifetime techn; | |
Real-world treatment outcomes in metastatic lung cancer : from efficacy-effectiveness gap evaluation to informed clinical decision-making | Welle C.M. van der | Klungel O.H., prof. dr. | Groen H.J.M., prof. dr. | Garde E.M.W. van de, dr. | Schramel F.M.N.H., dr. | Universiteit Utrecht (UU) | 2021 | Real-world data; Lung cancer; Treatment outcomes; Pharmacotherapy; Treatment patterns; Effectiveness; Survival; Pharmacoepidemiology; Web-based tool; |
Clinical manifestations of sex hormonal influences in migraine | Casteren D.S. van, PhD | Danser A.H.J., prof. dr. | Terwindt G.M., prof. dr. | Maassen van den Brink A., dr. | Universiteit Leiden (UL) | 2021 | Migraine; Clinical pharmacology; Treatment; Endocrinology; Pharmacology; | |
Salt, acid, and the renin-angiotensin system in chronic kidney disease | Bovée D.M., PhD | Hoorn E.J., prof. dr. | Danser A.H.J., prof. dr. | Erasmus Universiteit Rotterdam (EUR) | 2021 | Renin-angiotensin system; Kidney; Pharmacology; | ||
Investigations of skin inflammation with a novel dermatology toolbox for early phase clinical drug development | Kolk T. van der, dr | Burggraaf J., prof. dr. | Rissmann R, prof.dr. | Universiteit Leiden (UL) | 2021 | Skin inflammation Dermatology toolbox Early phase clinical drug development Trial at home Inflammation models Skin microbiome Atopic dermatitis | ||
The role of glomerular filtration and active tubular secretion in predicting renal clearance of drugs in children using population pharmacokinetic and physiology-based pharmacokinetic modeling approaches: unspinning the yarn | Cristea S., PhD | Knibbe C.A.J., prof. dr. | Allegaert K., prof. dr. | Krekels E.H.J., PhD | Universiteit Leiden (UL) | 2021 | Population PK; Optimise drug dosing; Paediatric renal clearance; PBPK; Paediatrics; Renal clearance; Population pharmacokinetics; Physiologically based pharmacokinetics; Maturation; Active tubular secretion; Renal transporters; | |
Osteoporotic fractures: relation to mortality, medication use, and rheumatoid arthritis | Abtahi S., PhD | Vries F. de, prof. dr. | Boonen A.E.R.C.H., prof. dr. | Driessen J.H.M., PhD | Burden A.M., dr. | Universiteit Maastricht (UM) | 2021 | |
Suurs F | Vries E.G.E. de, prof. dr. | Lub-de Hooge M.N., dr. | Rijksuniversiteit Groningen (RUG) | 2021 | Molecular imaging of immunotherapy biodistribution and the tumor immune environment | |||
Pharmacokinetic insights in individual drug response; a model-based approach to quantify individual exposure-response relationships in type 2 diabetes | Koomen J.V. | Lambers Heerspink H.J., prof. dr. | Mol P.G.M., dr. | Stevens J., Dr. | Rijksuniversiteit Groningen (RUG) | 2021 | Pharmacokinetic insights in individual drug response; a model-based approach to quantify individual exposure-response relationships in type 2 diabetes | |
Targeting the ileo-colonic region in inflammatory bowel disease | Gareb B | Kosterink J.G.W., prof. dr. | Frijlink H.W., prof. dr. | Rijksuniversiteit Groningen (RUG) | 2021 | Targeting the ileo-colonic region in inflammatory bowel disease | ||
Hibernating mitochondria, the cool key to cellular protection and transplant optimization; Mitochondrial aspects of hibernators and non-hibernators in hypothermia | Hendriks K.D.W. | Henning R.H., prof. dr. | Leuverink H.G.D., prof. dr. | Rijksuniversiteit Groningen (RUG) | 2021 | Hibernating mitochondria | ||
An orchestra in need of a conductor challenges and opportunities in multi-infusion therapy | Doesburg F | Touw D.J., prof. dr. | Rijksuniversiteit Groningen (RUG) | 2021 | multi-infusion therapy | |||
Better prediction of drug response in diabetic kidney disease | Idzerda N.M.A. | Lambers Heerspink H.J., prof. dr. | Zeeuw D. de, prof. dr. | Pena M.J., PhD | Rijksuniversiteit Groningen (RUG) | 2020 | Diabetic kidney disease; Drug response; | |
Therapeutic drug monitoring in tuberculosis treatment | Elsen S.H.J. van den | Alffenaar J.W.C., prof. dr. | Werf T.S. van der, prof. dr. | Rijksuniversiteit Groningen (RUG) | 2020 | drug monitoring, tuberculosis treatment | ||
Implementing dried blood spot sampling in transplant patient care | Touw D.J., prof. dr. | Touw D.J., prof. dr. | Bakker S.J.L., prof. dr. | Rijksuniversiteit Groningen (RUG) | 2020 | dried blood spot sampling, transplant patient care | ||
Implementing dried spot sampling in transplant patient care | Veenhof H. | Touw D.J., prof. dr. | Bakker S.J.L., prof. dr. | Berger S.P., prof. dr. | Rijksuniversiteit Groningen (RUG) | 2020 | dried blood spot; Transplantation; | |
Characterization and re-evaluation of experimental pain models in healthy subjects | Siebenga P.S | Cohen A.F., prof. dr. | Universiteit Leiden (UL) | 2020 | Analgesics Human evoked pain models Neuropathic pain Nociceptive pain Pharmacodynamics Phase-1 clinical triala | |||
Early phase clinical drug development for HPV-induced disorders: novel tools and treatments | Rijsbergen M. | Burggraaf J., prof. dr. | Rissmann R, prof.dr. | Poelgeest M.I.E. van, dr. | Universiteit Leiden (UL) | 2020 | HPV-induced diseases; | |
Rational use of antibiotics | Dijkmans A.C. | Burggraaf J., prof. dr. | Universiteit Leiden (UL) | 2020 | Antibiotics; Pharmacokinetics;Flucloxacillin;Penicillin; Pheneticillin;Rifampin;Colistin;Fosfomycin | |||
Integrated assessment of neurocognitive, neurophysiological and pain processing in early clinical drug development | Amerongen G. van, PhD | Gerven J.M.A. van, prof. dr. | Cohen A.F., prof. dr. | Groeneveld G.J., prof. dr. | Universiteit Leiden (UL) | 2020 | Clinical pharmacology Pharmacodynamics Pain Human pain models Cannabinoid GABA THC Multiple sclerosis (MS) | |
New therapeutic targets in cardiovascular disease: focus on the renin-angiotensin system and lipid metabolism | Sun Y | Danser A.H.J., prof. dr. | Lu X., PhD | Erasmus Universiteit Rotterdam (EUR) | 2020 | Renin-angiotensin system; lipid metabolism; Vascular reactivity; Pharmacology; Treatment options; | ||
Towards New Therapies for Preeclampsia: Restoring Vascular Dysfunction | Hitzerd AE | Reiss IKM, prof.dr. | Danser A.H.J., prof. dr. | Simons SHP, dr. | Erasmus Universiteit Rotterdam (EUR) | 2020 | Pre-eclampsia; Treatment options; Pregnancy; Pharmacology; | |
Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics: Tools of the trade | Goulooze S.C., PhD | Knibbe C.A.J., prof. dr. | Hankemeier T., prof. dr. | Krekels E.H.J., PhD | Universiteit Leiden (UL) | 2020 | Population pharmacokinetics-pharmacodynamics; Repeated time-to-event modelling; Paediatric pharmacology; Pharmacometric methodology; Analgesia; Iatrogenic withdrawal; Postoperative pain; Item response theory (IRT); Analgesia and sedation; Real-world data; Paediatrics; Pharmacodynamics; Pharmacometrics; | |
Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity: Studies in adults, adolescents and children | Smit C., PhD | Knibbe C.A.J., prof. dr. | Dongen H.P.A. van, dr. | Brüggemann R.J.M., PhD | Universiteit Leiden (UL) | 2020 | Obesity; Morbid obesity; Pharmacokinetics; Obese children; Obese adolescents; Gentamicin; Tobramycin; Aminoglycosides; Vancomycin; Renal clearance; Population pharmacokinetics; Antibiotics; Individualized dosing; Adolescents; | |
Mounting an attack on the glioblastoma triad : proliferation, invasion and resistance | Gooijer M.C. de, PhD | Beijnen J.H., prof. dr. | Tellingen O. van, dr. | Universiteit Utrecht (UU) | 2019 | Glioblastoma; Blood-brain barrier; Therapy development; Pharmacology; Cell biology; Combination therapy; Mouse models; | ||
Multi dose drug dispensing for older patients in primary care | Mertens B.J., PhD | Bouvy M.L., prof. dr. | Marum R.J. van, prof. dr. | Kwint H.F., dr. | Universiteit Utrecht (UU) | 2019 | Elderly; Primary care; Multi-dose drug dispensing; | |
Biomarkers in real-life COPD management | Oshagbemi O.A., PhD | Wouters E.F.M., prof. dr. | Vries F. de, prof. dr. | Franssen F.M.E., dr. | Universiteit Maastricht (UM) | 2019 | ||
Insight in disease and drug interactions, with treatment optimisation of patients with cancer | Knapen L.M., PhD | Tjan-Heijnen V.C.G., prof. dr. | Vries F. de, prof. dr. | Croes S., dr. | Erp N.P. van, dr. | Universiteit Maastricht (UM) | 2019 | |
Bioanalysis and biotransformation of tyrosine kinase inhibitors in oncology | Rood J.J.M., PhD | Beijnen J.H., prof. dr. | Sparidans R.W., dr. | Universiteit Utrecht (UU) | 2019 | |||
Biomedical engineering for breathomics: towards clinical application in respitaroty diseases biomarker, instruments and Technology Readiness Levels | Brinkman P., PhD | Sterk P.J., prof. dr. | Maitland-van der Zee A.H., prof. dr. | Jongh F.H.C. de, dr.ir. | Universiteit van Amsterdam (UvA) | 2019 | ||
Reversible suppression of hemostasis in hibernation and hypothermia | Vrij E.L. de | Henning R.H., prof. dr. | Bouma H.R., PhD | Rijksuniversiteit Groningen (RUG) | 2019 | Hypothermia; Hibernation; | ||
Use of real-world evidence in pharmaeconomic analysis | Huang Y. | Haaijer-Ruskamp F.M., prof. dr. | Postma M.J., prof. dr. | Rijksuniversiteit Groningen (RUG) | 2019 | Pharmacogenomics; | ||
Clinical pharmcology of ertapenem in the treatment of multidrug-resistant tuberculosis | Rijn S.P. van | Alffenaar J.W.C., prof. dr. | Werf T.S. van der, prof. dr. | Kosterink J.G.W., prof. dr. | Rijksuniversiteit Groningen (RUG) | 2019 | Tuberculosis; multidrug-resistant | |
Optimizing levofloxacin dose in the treatment of multidrug-resistant tuberculosis | Ghimire S. | Alffenaar J.W.C., prof. dr. | Touw D.J., prof. dr. | Werf T.S. van der, prof. dr. | Rijksuniversiteit Groningen (RUG) | 2019 | ||
Clinical pharmacology and therapeutic drug monitoring of voriconazole | Veringa A., PhD | Alffenaar J.W.C., prof. dr. | Kosterink J.G.W., prof. dr. | Werf T.S. van der, prof. dr. | Rijksuniversiteit Groningen (RUG) | 2019 | drug monitoring; voriconazole | |
The Clinical Pharmacology of performance enhancement and doping detection in sports | Heuberger J., dr. | Cohen A.F., prof. dr. | Groeneveld G.J., prof. dr. | Rotmans J.I., dr. | Universiteit Leiden (UL) | 2019 | Performance enhancement and doping detection in sports | |
Measuring pharmacodynamics in early clinical drug studies in multiple sclerosis | Kanhai K.M.S | Cohen A.F., prof. dr. | Groeneveld G.J., prof. dr. | Universiteit Leiden (UL) | 2019 | Multiple sclerosis Drug development Biomarkers Remyelination | ||
Fluorescence-enhanced surgical navigation : towards tailored tumor detection | Boogerd L.S.F., PhD | Velde C.J.H. Van de, Prof.dr. | Burggraaf J., prof. dr. | Vahrmeijer A.L., Dr. | Universiteit Leiden (UL) | 2019 | Fluorescence guided surgery tailored tumor detection Intraoperative tumor imaging ICG CEA targeted tumor detection | |
The quantification of growth hormone secretion : application of model-informed drug development in acromegaly | Esdonk M.J van | Graaf P.H., Prof.dr. | Burggraaf J., prof. dr. | Stevens J., Dr. | Universiteit Leiden (UL) | 2019 | Endocrinology Pulsatile profiles Population modelling Pharmacokinetic Pharmacodynamic modelling Clinical trial simulation | |
Vascular Effects of Current and Novel Antimigraine Drugs | Rubio Beltrán AE | Danser A.H.J., prof. dr. | Maassen van den Brink A., dr. | Erasmus Universiteit Rotterdam (EUR) | 2019 | Migraine; Vascular reactivity; Drug efficacy; Pharmacology; | ||
Peripheral Projections of the Trigeminovascular System as Antimigraine Target | Labastida Ramírez A | Danser A.H.J., prof. dr. | Maassen van den Brink A., dr. | Erasmus Universiteit Rotterdam (EUR) | 2019 | Migraine; Vascular reactivity; Pharmacology; | ||
The aging cardiovascular system: genetic and epigenetic determinants of vascular outcomes and cardiometabolic risk | Portilla Fernández E | Danser A.H.J., prof. dr. | Ikram MA, prof.dr. | Roks A.J.M., dr. | Dehghan A, dr. | Erasmus Universiteit Rotterdam (EUR) | 2019 | Cardiac aging; Cardiovascular disease; Genetics; Epidemiology; Epigenetics; Vascular reactivity; Pharmacology; |
Antifungal pharmacokinetics in the era of the obesity pandemic | Wasmann R.E., PhD | Burger D.M., prof. dr. | Knibbe C.A.J., prof. dr. | Brüggemann R.J.M., PhD | Radboud Universiteit (RU) | 2019 | Antifungal drugs; Clinical pharmacology; Morbid obesity; Micafungin; Anidulafungin; Posaconazole; Liposomal amphotericinB; | |
Comorbidities, complications and treatment of childhood obesity | Lentferink Y.E., PhD | Knibbe C.A.J., prof. dr. | Vorst M.M.J. van der, dr. | Universiteit Leiden (UL) | 2019 | Children; Obesity; Asthma; ADHD; Insulin resistance; Metformin; Cardiovascular diseases; Obese children; Arterial stiffness; Skin autofluorescence; | ||
Rational prescribing in Europe: are future doctors well prepared? | Brinkman D.J., PhD | Agtmael M.A. van, prof. dr. | Richir M.C., MD PhD | Tichelaar J., dr. | Vrije Universiteit Amsterdam (VU) | 2018 | Clinical pharmacology; Pharmacotherapy; Prescribing; | |
Osteoarthritis : association with diabetes mellitus, and treatment-related outcomes | Nielen J.T.H., PhD | Boonen A.E.R.C.H., prof. dr. | Dagnelie P.C., prof. dr. | Vries F. de, prof. dr. | Bemt B.J.F. van den, dr. | Universiteit Maastricht (UM) | 2018 | Osteoarthritis; Diabetes mellitus; Hip; Knee; Treatment outcomes; |
Learning in a student-run clinic: a new concept to improve medical education in pharmacotherapy | Schutte T., PhD | Agtmael M.A. van, prof. dr. | Richir M.C., MD PhD | Tichelaar J., dr. | Vrije Universiteit Amsterdam (VU) | 2018 | Pharmacotherapy education; Student-run clinic; Medical education; Workplace learning; Undergraduate education; | |
Angiogenic imbalance in preeclampsia: pathogenic, diagnostic and prognostic implications | Saleh L., PhD | Danser A.H.J., prof. dr. | Steegers E.A.P., prof. dr. | Meiracker A.H. van den, dr. | Visser W, Dr. | Erasmus Universiteit Rotterdam (EUR) | 2018 | Pre-eclampsia; Pregnant women; Pregnancy; Renin-angiotensin system; Treatment options; |
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